摘要

Objective To discuss the relationship between the specific radioactivity uptake of the bilateral striatum with 99Tcm-TRODAT-1 and UPDRS and evaluate the severity of Parkinson diseasePD from the point of imaging. Methods Fifty one patients with PD and a control group of 15 healthy subjects were applied dopamine transporterDAT imaging by SPECT with 99Tcm-TRODAT-1. The radioactive ratio between bilateral striatum and cerebellum(STCB) and the asymmetry indexAI of bilateral striatum were computed by using region of interestROI technology. Meanwhile the PD patients were classified by the improved Hoehn-Yahr disability score and then evaluated by UPDRS. Results There was a negative correlation between the bilateral STCB mean of the PD and the Hoehn-Yahr grading the UPDRS score the patients' self caring ability the ability to move. As for the asymmetry index there was also a negative correlation with the severity of PD. Conclusion There was a significant correlation between the specific radioactivity uptake of the bilateral striatum with 99Tcm-TRODAT-1 and UPDRS and it could monitor the state of PD and showed the symptom severity of PD evaluate the severity of PD.

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